澳门天天好彩

A History of the 澳门天天好彩

A History of the 澳门天天好彩

The 澳门天天好彩 as it exists today was established in 1993 to study the biological mechanisms underpinning human biology, health and ageing. Research on the 澳门天天好彩 estate actually dates back to the Institute of Animal Physiology established in 1948 to help the nation recover following the Second World War.


 

Before the Institute (pre-1948)

The name 澳门天天好彩 probably originates from the Anglo Saxon period (1000 to 1600 years ago), meaning the home of Barbara ("Badburgh"), thought to be the daughter of a local Chief. Yet historical evidence shows that people lived in and around 澳门天天好彩 as far back as the Mesolithic period (5000 to 15000 years ago).

Adeane

Much of the land around 澳门天天好彩 eventually came to be owned by the Church before being taken over by in 1539. The land passed through several owners until 1576 when Robert Taylor built the first great house on the 澳门天天好彩 estate. The construction of the hall and its gardens involved the demolition and re-siting of 澳门天天好彩 village to its present location.



The first house was demolished in 1768 by , Director of the , and a much simpler country house was constructed in its place. The modern 澳门天天好彩 Hall that forms part of the 澳门天天好彩 Research Campus is the third great house on the site and was built by Jones鈥 son (pictured right) between 1832 and 1837. The house was designed in the Jacobean style by . The Adeanes held the land through until the mid-20th century although it was leased to various tenants.



Download our History of 澳门天天好彩 and 澳门天天好彩 Archaeology booklets to discover more about our history prior to World War II.


 

The Institute of Animal Physiology (1948 to 1993)

Daly

In the wake of World War II, Britain recognised the need for research into more sustainable and independent agricultural practices to help the nation recover and to be better prepared for any future hardships. In 1948 the 澳门天天好彩 estate was purchased from the Adeanes by the to create the national Institute of Animal Physiology (IAP) with (pictured left) as its founding Director.



The new Institute saw extensive changes inside the Hall. The breakfast room became one of the first laboratories and an operating theatre. The drawing room became laboratory stores, and workshops and darkrooms were installed in the basement. This period also saw the construction of various lab huts on the site (shown below) as well as the creation of our on-site accommodation as a way to support researchers relocating into the area.



A decade after founding the IAP, Professor Daly stepped down as Director, passing responsibility to , a renowned pharmacologist known for studying the effects of drugs on nerve communications. In 1964 the mantle then passed to , a physiologist and great-grandson of Charles Darwin.



joined the Institute in 1952. In 1965 he produced early evidence to suggest are made of double layers of lipid molecules. He also discovered 鈥楤anghasomes鈥 simplified lipid structures now known as liposomes. helped scientists to examine the structure and organisation of cells and have since been investigated as a way to target drugs and other substances for targeted delivery to specific cells.

Daly Labs

, physiologist, took over the Institute鈥檚 Directorship in 1974. He would become the Institute鈥檚 longest serving Director, holding the role until 1989.



In 1977 a collaboration between Geoff Butcher and Jon Howard with C茅sar Milstein () at the (LMB), led to the first 鈥榰seful鈥 . This work has allowed scientists to use antibodies to track cells and proteins in their studies and has resulted in several monoclonal antibody drugs such as and .

Azim Surani

Work published by Professor Azim Surani FRS (shown left) in 1984 revealed the discovery of mammalian . Although we have two copies of most genes, one from each parent, imprinting means that, for some genes, we rely more on one copy than the other. This provided a crucial fundamental insight into genetics and development. Professor Wolf Reik FRS (then a postdoctoral researcher) would later work alongside Surani to show that imprinting is driven by an epigenetic system of DNA methylation. Reik lead a group at the Institute until 2022.



In 1986, the IAP joined with two organisations based in Roslin, Scotland to form the Institute of Animal Physiology & Genetics Research (IAPGR) with funding from the (AFRC). During this time, the IAPGR worked on developing the cloning techniques that would eventually produce Dolly the Sheep at Roslin in 1996.



1989 saw become the new Director. Heap was a specialist in studying the role of hormones in animal reproduction. He would oversee the final years of the IAPGR and the creation of the 澳门天天好彩.


 

The 澳门天天好彩 (1993 onwards)

Staff in 1993

The early 1990s saw shifts in national research priorities and the Institute became the responsibility of the formed from the AFRC. In 1993, the 澳门天天好彩 (1993 staff picture shown left) was created from the Cambridge-based part of the IAPGR, while the Scottish part became the , now part of the . Over the next five years, agricultural research was phased out and our major focus shifted to understanding the biology underpinning human development, health and ageing.



The monoclonal antibody techniques we developed with the MRC-LMB in the 70s were licensed for commercial development in 1993. The work was taken forward by Abgenix, who were by Amgen 15 years later. Abgenix developed which is now used to treat certain bowel cancers.

Aerial view

Dyer

Richard Dyer (shown left) took the lead of the Institute from Brian Heap in 1994. Dyer specialised in understanding how nerves regulate hormone release. Dyer鈥檚 vision was of an integrated 澳门天天好彩 Research Campus that would unite academics and commercial research scientists in one place to give more rapid development of new discoveries into impacts and applications.



1994 saw the Institute host its first annual Schools' Day. Each year we open our doors to secondary school and sixth form students for a day so that they can come into our labs and find out more about what it's like to pursue a career in research, while also learning more about the latest science. Schools' Day is still part of the Institute calendar today.



In 1996, the Institute created the company 澳门天天好彩 Bioscience Technologies Ltd. with responsibility for developing the . Their goal was to find small-scale organisations with complementary interests to the Institute and enable them to come and work alongside us on the Campus. Initially new companies worked in existing laboratories alongside the Institute (shown; the Campus as it appeared in 1998). The company changed its name to 澳门天天好彩 Research Campus Ltd. in 2021.



By 1998, all research involving large animals had ceased on the site. Current research at the Institute uses rodents (mainly mice) or alternative systems such as tissue culture, organoids and computer models.



Collaboration with the MRC-LMB in 1999 led to the first detailed structure of the lipid signalling protein PI3K gamma. This unlocked new possibilities for designing and developing drugs to control this protein and others like it. Since are key in controlling cell growth and have been linked to various illnesses, these drugs could have widespread applications.



For a complete exploration of our work on PI3 kinases and their subsequent investigation as drug targets download our cell signalling timeline posters.


 

The 2000s

Research highlighted the importance of genomic imprinting mechanisms discovered in the 1980s. The work shows that imprinting affects how quickly babies grow before birth by changing how easily nutrients pass through the placenta from mother to baby.



In the same year, we developed a new method called . The technique allowed better antibodies to be created that could more precisely find their correct targets. This further improved their potential for use as cell or protein trackers in research and as drugs in the clinic. The technology was later developed by a spin-out called Discerna and subsequently by .

Original bioincubator buildings

Also in 2002, we genes can be regulated by genetic sequences that are a long way from the genes themselves. We now know that DNA inside cells can form loops bringing distant genetic sequences close together inside the cell and this can have a dramatic effect on the activity of many genes.



Between 2005 and 2012, the first custom Bioincubators 鈥 Minerva, Meditrina, Maia and Moneta (shown left) 鈥 were built on the south side of the Campus, providing new spaces for companies coming to the Campus. This period also saw the demolition of some of the original IAP buildings.



Between 2005 and 2007, Dr John Bicknell became acting Director until Professor Michael Wakelam took the reins. Director from 2007 until his untimely death in 2020, Wakelam was an expert in lipid biology and played a key role in the development of lipidomics research 鈥 simultaneously studying the roles of all lipids inside cells.



Crescendo Biologics Ltd. was founded as a spin-out from the Institute in 2008. Crescendo鈥檚 goal is to use antibody techniques that were developed here to develop better antibody-based anti-cancer therapies. In 2018 agreed an exclusive license to further develop some of Crescendo's potential therapies.



In 2009, the Institute opened the present Biological Support Unit (BSU) animal facility on the Campus, which has since been extended to add more capacity. The BSU is a specialist small-animal research facility and is a global flagship for animal welfare, animal technician training and staff wellbeing.


 

The 2010s

2010 saw the Institute working with the Department of Health to examine the effects of mobile phone radiation on health.



In 2011, we worked in partnership with the National Institute for Medical Research to reveal how by supporting cells in the immune system.

Concordat logo

2014 was the year we became a founding signatory of the , this further consolidated our commitment to being open about our research using animals and working together with the public on the issues surrounding animal research. Our commitment to the Concordat has been recognised several times, including a commendation for providing visitors with virtual tours of our animal facility and an award for our work with schools on the practicalities and ethics of research using animals.



Our in 2013 demonstrated that plays a key role in the capacity of stem cells to produce a wide variety of different types of cells (), a critical part of development. Understanding stem cells underpins the concept of 鈥 a future type of medicine that could allow us to grow and replace whole body parts.



In 2013 the first views of how DNA is arranged inside cells. These insights into chromosome architecture help us to understand how genes are regulated in different types of cells. In 2017, we worked with visual artist Andy Lomas and musician Max Cooper to create an immersive VR experience called CHROMOS based on this research.



With colleagues at the University of Cambridge, this was also the year that we discovered a new human genetic condition that is responsible for recurrent lung infections. , affects the immune system and increases the risk of infections. We鈥檙e now using our expertise with PI3K to find new treatments for this illness.

Bioincubator buildings

Further development of the Campus from 2013 to 2015 led to the Jonas Webb, Eddeva and Bennet buildings (shown right) on the north side of the campus. 2013 also saw the establishment of 澳门天天好彩 Commercialisation Services (now 澳门天天好彩 Enterprise Ltd.) which facilitates the commercialisation of Institute research in partnership with companies.



In 2014 we joined the network of 13 life science research institutes across Europe. The goal of EU-LIFE is to build collaborations, develop careers, share best practice and expertise while also representing the scientific community as an influential voice in European scientific policy. With EU-LIFE colleagues we have secured funding for and projects which respectively investigate ways to improve equality and openness in science.



Thanks to funding from the , in 2016 we launched new work investigating the effects of ageing on health in developing countries, particularly looking at the effect of age on the immune system and the body鈥檚 capacity to protect itself from disease.



In 2017 a third round of Campus expansion was announced. Biomed Realty would provide two further buildings with flexible space and facilities to support larger companies.

RATAC logo

Our research in 2017 leads to an epigenetic ageing clock that can be used to measure the rate of ageing in mice; the most precise way to track the ageing process. The is that the epigenetic clock could help us to find ways to slow biological ageing. We also show that restricting the diet of mice can significantly extend their lifespans. This work formed the basis of the Race Against the Ageing Clock public exhibit launched at the Royal Society in 2018.



In 2018, we found a mechanism that gut bacteria can use to control some of our genes.

cell section

Our work as part of the Deciphering the Mechanisms of Developmental Disorder consortium led to one of the first systematic studies of gene effects in the placenta (placenta cells shown right) and showed that many more genes than expected could contribute to prenatal deaths. This research was led by Dr Myriam Hemberger (now at the University of Calgary) who went on be a winner of the for research into reporduction and women's health.



In September 2018, we worked together with other research organisations in Cambridge to launch LifeLab, a public celebration of European-funded research that formed part of the European Researchers Night that takes place each year across Europe.



This year's research also led to a possible new way to tackle the common cold, by targeting fatty molecules called lipids.





In 2019-2020 the Institute experienced an exciting phase of new growth. Our work on human health and ageing continued with our research focusing on three key areas: epigenetics, signalling and immunology. We recruited new group leaders to expand and enhance our scientific expertise and explore exciting new directions of inquiry, welcoming Dr Hayley Sharpe () and Dr Rahul Samant (October 2019 announcement) to the Signalling programme to explore the biology of protein tyrosine phosphatases and protein folding respectively. Dr Maria Christophorou joined the Institute鈥檚 Epigenetics programme in January 2020 (announcement) to work on the mechanisms that modulate the function of epigenetic regulators.

 

Technician Commitment logo

Our research facilities also expanded their capacities and continued to provide vital services to the Institute and other local organisations. The 澳门天天好彩 Research Campus too continued to grow, now hosting around 60 commercial organisations with more to come following the completion of the Biomed@澳门天天好彩 development. Michael Wakelam shared his thoughts on the importance of personal development and the importance of nurturing the individual to enable the best environment for the best research in a Vision piece for the FEBS Network (staff photo 2018 shown below). The Institute was also proud to become a signatory of the Technical Commitment, pledging to increase recognition and support for Institute鈥檚 community of technical specialists who contribute essential technical expertise in vital roles across the Institute.


 

To discover more about our current research, head over to our research pages and latest news and read more about the groups currently working at the Institute. Our present a year-by-year look at our research from 2016 onward.To explore some selected highlights and research stories have a look through our research features, and for personal perspectives on life at the Institute, careers, public engagement, knowledge exchange, sustainability and equality, visit our blog.

 

Staff in 2018