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Research Groups

Group Leaders

The ò’s research focuses on understanding fundamental biology and its role in healthy ageing and disease. Our research groups form three strategic research programmes; Epigenetics, Signalling and Immunology. You can discover more about all our research groups below, and the list includes honorary group leaders and associate group leaders affiliated with a specific research programme. In addition, the Institute operates several scientific facilities. Each facility employs a specialist team with skills and expertise in key cutting-edge research techniques.

 

Christophorou lab image

How mechanisms that modulate the function of epigenetic regulators are perturbed in disease and how they may be targeted for therapeutic effect. 

 

 

The role of protein kinases in cellular responses to growth factors, nutrient availability or stress and damage. 

 

 

Understanding the role of chromatin and nuclear organisation in controlling gene expression during the development of the immune system. Associate group leader hosted by

 

 

David

Understand the molecular basis of ageing by focusing on protein aggregation - a pathological adaptation to ageing. 

 

 

Yiliang-Ding-summary

The role of RNA structure in gene regulation with a focus on understanding the dynamics of RNA structure in living cells. Honorary group leader in

 

 

The role of autophagy and other cellular ‘eating’ processes in normal biology and during ageing or disease. 

 

 

The molecular mechanisms and physiological significance of signalling networks involving phosphoinositide 3-kinases (PI3Ks). 

 

 

The mechanisms by which cells learn to adapt and thrive in new environments. 

 

 

Howard

Using mathematical modelling to rationalise complex biological dynamics into simple underlying mechanisms. Honorary group leader in

 

 

The epigenetics of the egg and sperm and their role in carrying information between generations. 

 

 

How autophagy contributes to health and healthy ageing by eliminating damage and recycling cell components. 

 

 

Understanding the changes that occur in T cells with age that contribute to the age-dependent decline in the germinal centre response. 

 

 

The role of regulatory T cells in controlling and suppressing the immune system and the effect of age on these cells. Honorary group leader in

 

 

McGough

How signalling pathways change in ageing organs and how such changes affect organ function. 

 

 

Trophoblast

Investigating the mechanisms that direct ‘cell fate’ in human embryos and stem cells. Honorary group leader in

 

 

O'Donnell

The study of bioactive lipids in circulating blood cells, particularly platelets. Honorary group leader in

 

 

Rayon research image

How regulatory and dynamic processes control timing in development and homeostasis.  and

 

 

The role of epigenetics in cell identity and factors involved in the process of epigenetic reprogramming. Honorary group leader in

 

 

The molecular mechanisms underlying diversification of antibody genes by B cells in the immune system. 

 

 

Arianne Richard research image

How T cells sense and integrate information from both infection and the physiological environment to generate appropriate immune responses.

 

 

Cell images

The epigenome in stem cells and development, and how epigenetics changes through the life course. 

 

 

Samant sections

Investigating the plasticity of protein clearance pathways in young, aged, and diseased cells. 

 

 

The functional organisation of the genome in three dimensions. 

 

 

Sharpe sections

Understanding how the cells that make up our tissues and organs communicate. 

 

 

The molecular mechanisms and physiological significance of signalling networks involving phosphoinositide 3-kinases (PI3Ks). 

 

 

Kai-Michael Toellner

Kai Toellner research image

Studying how lymphocytes respond to vaccination or infection, including the mechanisms of antibody protection, auto-immunity and changes to these mechanisms with age. Immunology.

 

 

Trefely

Providing fundamental insights into the role of nuclear metabolism in ageing and metabolic syndrome. /

 

 

Gene expression and the roles of RNAs in the development and function of lymphocytes. 

 

 

Voigt

Understanding the molecular mechanisms that control the accurate and timely expression of genes during development. 

 

 

Control of cell shape, movement, gene expression and other factors by Rac-GEF proteins. Associate group leader hosted by